After her husband Martin completes a four-year prison sentence for insider trading, Emily Taylor drives into a wall in an apparent suicide attempt. Jonathan Banks, her assigned psychiatrist, prescribes a series of antidepressants, but none work. Jonathan contacts Emily's previous psychiatrist, Victoria Siebert, who suggests an experimental new drug, Ablixa. The drug seems to help Emily, but gives her sleepwalking episodes as a side effect. One night, Emily stabs Martin to death while sleepwalking. Jonathan fights for Emily's acquittal in court. She pleads insanity and is declared not guilty on the condition that she stays in a psychiatric hospital until cleared by Jonathan. The publicity destroys Jonathan's reputation, and his colleagues assume negligence on his part.